What is the periapical lesion size depended on? Probably it has a correlation with number of intracanal microorganism’s taxons and number of microbiota itself. Does the periapical lesion size has an influence on a decision making process? Most of my referring dentists DO believe so. That’s why I got this patient for the consult firstly. Usually I see it as a sign that RD has a doubts whether tooth could be saved.